Sherburne County offers excellent transportation linkages to the rest of the state and nation. Two four-lane U.S. Highways (169 and 10) provide excellent access to Minneapolis-St. Paul, St. Cloud, North Dakota, northern Minnesota and beyond. Three Minnesota highways provide direct access to Interstate 94. The BNSF main line from Chicago to Seattle traverses the county, providing rail service to business parks adjacent to U.S. Highway 10.

Public airports are located in St. Cloud, Princeton and Clear Lake.